The Giallorossi have faltered in recent weeks and they now find themselves three points off the European places.
Meanwhile, Inter can keep up the pressure on third-placed Lazio with a win in the Italian capital.
Roma: Goicoechea; Burdisso, Leandro, Marquinhos; Piris, De Rossi, Bradley, Balzaretti; Pjanic, Florenzi; Destro
Inter: Handanovic; Silvestre, Cambiasso, Chivu; Jonathan, Zanetti, Benassi, Pereira; Milito, Guarin, Cassano
Sports Mole says: 1-2