Paulo Fonseca's side will enter the match off the back of a 2-1 victory over Parma on Wednesday, while 19th-placed Brescia suffered a 3-1 loss at Torino on the same night.
Brescia are in danger of immediately dropping back into Serie B, with Diego Lopez's side facing a huge battle to secure their status as a top-flight club for the 2020-21 campaign.
Indeed, a return of 21 points from 31 matches has left Le Rondinelle in 19th position in the table, seven points behind 17th-placed Lecce, which is a lot at this stage of the season.
It is going to take some effort from Lopez's team to escape the relegation zone, although there is still a lot of football to be played, with the Serie A season not concluding until the start of August.
Brescia have struggled for positive results at home this season, though, picking up just 10 points from their 15 matches, which is the second-worst record in Serie A behind basement side SPAL.
Roma, meanwhile, appear to be locked in a three-way battle with Napoli and AC Milan for fifth place.
A top-four position looks to be beyond Fonseca's side as they trail fourth-placed Inter Milan by 13 points, but the Yellow and Reds will be determined to claim fifth, which would be an improvement on last season.
Roma's form immediately after lockdown was poor, losing three of their four league matches between June 24 and July 5, including defeats to Milan and Napoli.
Roma's away form this season has also been relatively strong, losing just five of their 15 Serie A matches on their travels, picking up seven victories in the process.
Brescia Serie A form: LDDLWL
Roma Serie A form: WWLLLW
Sandro Tonali continues to be linked with some of Europe's biggest clubs, and the 20-year-old will again be keen to make an impression for the hosts in the middle of the park.
Justin Kluivert will be hoping for a return to the squad, having allegedly been left out against Parma due to concerns over his attitude in training, while Davide Zappacosta is also in line to feature.
Brescia possible starting lineup:
Joronen; Sabelli, Papetti, Mateju, Martella; Spalek, Dessena, Tonali, Bjarnason; Donnarumma, Torregrossa
Roma possible starting lineup:
Lopez; Mancini, Cristante, Ibanez; Zappacosta, Zaniolo, Veretout, Spinazzola; Mkhitaryan, Dzeko, Pellegrini
We say: Brescia 0-2 Roma
Roma will be determined to pick up all three points as they battle for fifth, and we are finding it difficult to predict anything other than an away win. Brescia are capable of making it an uncomfortable game for the visitors, but it is tough to back Lopez's side considering their struggles this term.