The league leaders took a major step closer to the trophy on Saturday with a 2-0 win over Nacional, while the hosts' survival bid was marginally improved with a 0-0 draw away against Portimonense last time out.
Rio Ave come into this game in the back of a goalless draw with fellow strugglers Portimonense, as Miguel Cardoso's men failed to break the deadlock for what would be a crucial victory, despite dominating the majority of the encounter.
That stretched their winless run to eight games in the top flight, having suffered losses in important matches at the bottom of the table against Maritimo and Gil Vicente.
In those eight games, Os Rioavistas picked up six points while netting just five goals.
As a result, Cardoso's men have fallen worryingly close to the relegation zone, now sitting just two points ahead of Boavista in the relegation playoff place and four points above the automatic drop zone.
With 12 points left to play for, Os Rioavistas will be desperate to put a crucial victory on the board to fend off the bottom three, but they face a tough test as the league leaders travel to the Estadio dos Arcos.
Sporting will look to go one step closer to lifting the 19th Primeira Liga trophy in the club's history, and their first since 2002.
Following a slightly inconsistent patch of form, Ruben Amorim's men got their title bid firmly back on track with consecutive victories coming into Wednesday's game.
They took 83 minutes to break the deadlock at home to basement side Nacional last time out, but Zouhair Feddal eventually opened the scoring before Jovane Cabral netted a penalty in added time to seal their 23rd league win of the campaign.
Amorim's men will also look to continue their league unbeaten run, having not suffered a defeat from any of their 30 games in the top flight this campaign, accumulating an impressive tally of 76 points from those matches.
That is in no small part down to their strong defensive record, with no side in the league conceding as few as the 15 goals that Os Leoes have shipped in 30 games, while also registering an eye-catching tally of 54 goals at the other end of the pitch.
With a six-point lead over second-placed Porto after 30 games of the campaign, Os Verde e Brancos now require just seven points to seal the title, and Amorim will be hopeful of his side picking up a third consecutive victory to take a huge step closer to that aim.
Rio Ave will be boosted by the return of experienced full-back Ivo Pinto, who served a suspension last time out for a red card.
Goalkeeper Antonio Adan will return to the Sporting Lisbon XI after serving a suspension last time out.
The experienced Spanish stopper has kept an impressive tally of 17 clean sheets in 29 league games this season, and he will take his spot back from Luis Maximiano, who deputised in his absence for the Nacional victory.
Rio Ave possible starting lineup:
Kieszek; Pinto, Borevkovic, Santos, Amaral; Geraldes, Augusta, Guga; Coentrao, Brandao, Dala
Sporting Lisbon possible starting lineup:
Adan; Inacio, Coates, Feddal; Porro, Mario, Palhinha, Mendes; Goncalves, Paulinho, Santos
We say: Rio Ave 0-2 Sporting Lisbon
Despite Rio Ave's growing need for a win, the league leaders should be too strong for Cardoso's men on Wednesday.
With the title firmly in their sights, we expect Os Leoes to grind out another victory built on their solid back line.