Long is yet to score for club or country in eight matches this season, but the Southampton forward gets another chance to impress in his nation's crucial game on Friday night.
Realistically, Ireland must win the fixture at the Aviva Stadium to maintain their hopes of securing a place in November's playoffs after Wales registered a 1-0 victory in Georgia.
Republic of Ireland: Randolph; Christie, Clark, Duffy, Ward; Hoolahan, Meyler, Hendrick; Murphy, Long, O'Dowda
Moldova: Cebanu; Bordian, Racu, Epureanu, Razgoniuc, Platica, Gatcan, Anton, Ionita, Dedov, Ginsari
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