Valladolid are currently 19th in La Liga, having picked up just 10 points from their 12 matches this term, while Osasuna are just one point and one position above their opponents in the table.
Valladolid picked up two huge results either side of the November international break, recording a 2-1 win over Athletic Bilbao before overcoming Granada two weeks later; a point at home to Levante followed, but the strugglers suffered a 2-0 defeat at Atletico Madrid last weekend.
Despite a relatively strong recent run of results, Sergio Gonzalez's side are inside the relegation zone, having won two, drawn four and lost six of their 12 matches this term to collect 10 points.
Valladolid are actually only three points behind 13th-placed Valencia, though, and it is incredibly tight in the bottom half of the division, with even basement side Huesca just three points from the safety of 17th.
The White and Violets, who have former Brazil striker Ronaldo as a majority shareholder, finished 13th last season and would have been looking to build on that impressive position this term.
The early indications are that it could be a tough campaign for the club, though, and recent history favours Osasuna in this fixture, with Valladolid without a victory over their opponents on Friday since November 2012.
Osasuna were excellent on their return to La Liga last season, ultimately claiming 10th spot, just four points off the Europa League positions as they picked up 52 points from 38 matches.
Los Rojillos have struggled for consistency in the early stages of 2020-21, though, and currently sit 18th in the table, having collected 11 points from their 11 matches thus far.
Jagoba Arrasate's side are actually without a win in Spain's top flight since overcoming Athletic Bilbao on October 24, losing four of their last five matches during a worrying run.
Atletico, Sevilla, Barcelona and Real Betis have all beaten Osasuna since the end of October, while the club were held to a 1-1 draw by basement side Huesca on November 20.
Each of the last three La Liga meetings between Osasuna and Valladolid have finished level, including a 1-1 draw in the corresponding match during the 2019-20 campaign.
Real Valladolid La Liga form: LLWWDL
Osasuna La Liga form: WLLDLL
Sergio is expected to keep faith with the majority of the side that started against Atletico last weekend, although there could be a change in the final third with Shon Weissman potentially replacing Maranhao.
Nacho Vidal and Kike Barja came off the bench against Betis, meanwhile, and are options for change, but Ante Budimir and Ruben Garcia are likely to retain their positions in the final third of the field.
Real Valladolid possible starting lineup:
Masip; Hervias, Bruno, Sanchez, Nacho; Jota, Alcaraz, Mesa, Plano; Weissman, Maranhao
Osasuna possible starting lineup:
Herrera; Roncaglia, Aridane, D Garcia, Perez; Torres, Oier, Moncayola, R Garcia; Budimir, Calleri
We say: Real Valladolid 1-1 Osasuna
There is not an awful lot between these two teams in terms of quality, and as mentioned, the pair have played out three successive draws. Valladolid are arguably the favourites due to their recent run of form and the fact that they have home advantage, but we fancy Osasuna to pick up a share of the spoils.