The Portuguese international has been frequently linked with a return to former club Manchester United, and recently took to Twitter to deny claims that he had agreed a new deal with the La Liga giants.
However, this raises no concern for Perez, who is confident that Ronaldo will remain at the club for a long time to come.
"Cristiano made these statements because there was some information in the media which did not match reality," Perez told 20minutos.
"Soon we will clarify this issue. I have no doubt that Cristiano is going to retire at Real Madrid. I am convinced that he will renew.
"[Renewing with Ronaldo] is our most important activity, around whom we can build the Madrid of the future."
Ronaldo has also been the subject of interest of AS Monaco.