Carlo Ancelotti again deploys Sergio Ramos in midfield against Sevilla after the centre-back was used alongside Toni Kroos during Real Madrid's 4-2 win over Celta Vigo.
The Italian makes five changes to the side that beat Almeria in midweek as Asier Illarramendi makes way for Ramos.
Iker Casillas also returns to the starting lineup in place of Keylor Navas, with Marcelo and Dani Carvajal replacing Alvaro Arbeloa and Fabio Coentrao in the full-back positions.
Sevilla boss Unai Emery keeps Carlos Bacca in the starting XI after the Colombian netted twice against Eibar on Wednesday evening.
Sevilla: Rico, Figuerias, Carrico, Kolo, Tremoulinas, Krychowiak, Mbia, Vidal, Banega, Reyes, Bacca
Real Madrid: Casillas, Carvajal, Varane, Ramos, Pepe, Marcelo, Ronaldo, Kroos, James, Isco, Hernandez
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Sam McEvoy
