Los Blancos are just two victories away from clinching the title, but Granada have top-six ambitions and will enter this match off the back of a three-game unbeaten run in Spain's top flight.
Granada secured a return to La Liga for the current season courtesy of finishing second in the Segunda Division last term and therefore consolidating at this level was always going to be their number one target.
El Grana have not finished higher than 15th in Spain's top flight since the 1973-74 campaign but are currently in the mix for a top-six spot, which would be some achievement for the newly-promoted side.
As it stands, Diego Martinez's side are ninth in the table, just three points behind sixth-placed Getafe as they bid to sneak into the Europa League positions.
Granada actually struggled for form immediately after the lockdown period, but they have picked up seven points from their last three matches and recorded an impressive 3-2 victory at Real Sociedad on Friday.
The capital giants are now four points clear of second-placed Barcelona, who will be looking to stay in touch when they face Real Valladolid on Saturday night.
Should the reigning champions lose against Valladolid then Madrid can clinch the title by beating Granada, but it would be a surprise if the title race was not still live entering the final two games of the season.
Regardless of what Barca manage to do in their final three matches, two wins would be enough for Zidane's side to wrestle the title away from the Catalan giants, which would be some achievement.
Madrid have been in wonderful form since returning to action last month, winning all eight of their league matches, including each of their last three on their travels.
Granada La Liga form: LDLWDW
Real Madrid La Liga form: WWWWWW
Martinez is largely expected to keep faith with the side that started at the Anoeta, although there will be some changes to guard against fatigue.
Granada possible starting lineup:
Silva; Foulquier, Diaz, Vallejo, Duarte, Neva; Machis, Herrera, Azeez, Puertas; Soldado
Real Madrid possible starting lineup:
Courtois; Carvajal, Varane, Ramos, Mendy; Kroos, Casemiro, Valverde; Hazard, Benzema, Asensio
We say: Granada 0-2 Real Madrid
Granada's recent form must be respected, but it is difficult to see the home side stopping Madrid on Monday night. Zidane's side are well on course to lift the title, and we fancy them to put another hugely important victory on the board ahead of their final two matches of the campaign against Villarreal and Leganes.