The reigning champions remain without Raphael Varane (abductor) and Sergio Ramos (hamstring) for the time being, so Nacho Fernandez and Eder Militao will form a protective barrier in front of Thibaut Courtois.
Alvaro Odriozola started against Sevilla but thigh discomfort prevented him from training fully earlier this week, and with Dani Carvajal and Lucas Vazquez both on the treatment table, Federico Valverde may have to fill in at right-back.
On the other side of defence, Zidane is hit with the absence of Ferland Mendy with a calf issue, while Marcelo is not thought to be at 100% fitness either, so 19-year-old Miguel Gutierrez could make his first senior start for Los Blancos.
Hazard should be fit enough to displace Vinicius Junior on the left after his late equaliser on Sunday, with the two wingers once again supporting Karim Benzema as he aims to avoid a fourth La Liga game without a goal.
Real Madrid possible starting lineup: Courtois; Valverde, Militao, Nacho, Gutierrez; Casemiro, Kroos, Isco; Asensio, Benzema, Hazard