The hosts have won their last three league matches, the latest coming against Osasuna last Sunday.
However, they were knocked out at the quarter-final stage of the Copa del Rey in midweek by Atletico Madrid.
Real progressed to the semi-finals of the same competition on Tuesday when they beat Espanyol 1-0.
Athletic Bilbao: DWLWWW
Real Madrid: DWWWWW
Possible starting lineups
Athletic Bilbao: Iago; Iraola, San Jose, Laporte, Balenziaga; Iturraspe, Rico; Susaeta, Gomez, Muniain; Aduriz
Real Madrid: Lopez; Carvajal, Pepe, Sergio Ramos, Marcelo; Alonso, Modric, Di Maria; Bale, Benzema, Ronaldo
Sports Mole says: 1-3