Ahead of Saturday's encounter, the Catalan giants have a four-point lead over Madrid at the top of the league table.
Summer signing Luis Suarez is expected to play a role at the Bernabeu after coming to the end of his four-month ban for biting the shoulder of Italy's Giorgio Chiellini at the World Cup.
"There is such a long way to go it will not be decisive," Enrique told reporters. "We will approach the game as Barcelona always have going to the Bernabeu in the last few years, trying to be better than our opponent and get a positive result."
Barcelona have not lost a league game so far this season, while Madrid have won their last five.