The Blancos travel to San Mames knowing that they could move top of the Primera Division table depending on how local rivals Atletico fare at home to Real Sociedad.
However, with Bilbao looking to consolidate their Champions League qualification place in the standings, the Italian coach anticipates a tough test for his team tonight.
He told reporters: "Athletic are a great team, very dangerous and with very dynamic football.
"To win at San Mames you have to give more than 100%. It is a very difficult game and a good test for the League."
Bilbao have not lost in the league at home this season.