The current La Liga champions travel to the Bernabeu trailing leaders Los Blancos by four points.
Despite the importance of the match, the Brazilian has claimed that he is relishing the prospect of the possible title decider.
"A Clasico is the best game you can play, not counting cup finals," Alves told GoIT.
"When you really like football it's the most desired game. When you play football professionally, the Clasico is the best game to play and I can't wait.
"I was happy, delighted [in 2011-12 when Madrid and Barca played in the Champions League semi-final and the Copa del Rey semi-final] because the game I like was repeated four or five times."
Barcelona will also face Madrid in the final of the Copa del Rey next month.