Levante vs. Sevilla (Wednesday, 6.00pm)
With five wins in their last six league games, Sevilla are the most in-form side in the division and could leapfrog Real Madrid and Barcelona into second place with a win on Wednesday evening.
We say: Levante 1-3 Sevilla
Sevilla are really the big dogs in the league right now and, with the firepower Lopetegui's men have at their disposal, it does not look like Levante will be able to find a way to best them. We are going with a 3-1 scoreline.
Osasuna vs. Valencia (Wednesday, 6.00pm)
A dead rubber in many respects, bragging rights are still very much up for grabs in this contest as both sides strive to salvage seasons struck by snags and setbacks.
We say: Osasuna 1-1 Valencia
We are not expecting anything spectacular from this clash, with both sides edging closer to relatively unspectacular mid-table finishes. A touch of class from the likes of Ruben Garcia, Guedes or Soler would certainly get the fans out of their seats.
Real Betis vs. Athletic Bilbao (Wednesday, 7.00pm)
This encounter will be the first league game Athletic have played since their 4-0 defeat to Barcelona in the final of the Copa del Rey, the team's second final defeat in the space of just two weeks.
We say: Real Betis 2-0 Athletic Bilbao
Betis have really upped the ante in recent weeks, and we think Pellegrini's men have the upper hand on Athletic at this point in time. We are going for a 2-0 win with goals from Canales and Fekir.
Alaves vs. Villarreal (Wednesday, 8.00pm)
Villarreal will know that three points could see them haul themselves into fifth place, leapfrogging both Real Betis and Real Sociedad.
We say: Alaves 1-2 Villarreal
We think Villarreal have what it takes to come away with the points in midweek. Alaves are playing with desperation on their side, but Emery's men just have too much firepower behind them.
Elche vs. Real Valladolid (Wednesday, 8.00pm)
A win for either of these two sides could see them haul themselves out of the bottom three.
We say: Elche 2-2 Real Valladolid
A relegation six-pointer this late in proceedings is always a tough one to call, and we think these two outfits will scrap until the last minute. We are going with a 2-2 draw.
Cadiz vs. Real Madrid (Wednesday, 9.00pm)
Real Madrid will endeavour to get their La Liga title charge back on track when they travel to Cadiz for Wednesday night's fixture.
Both teams played out goalless stalemates in their most recent games, with Cadiz and Celta Vigo cancelling each other out while Los Blancos could not find a way past Getafe.
We say: Cadiz 0-2 Real Madrid
Cadiz, with their fond memories of facing the champions and newfound defensive resilience, can certainly trouble a Real Madrid team constantly bedevilled by a lengthy absentee list.
However, any more points dropped could signal the beginning of the end of Real's title charge, and Zidane has more options to work with this week, so we expect the champions to return to winning ways in straightforward fashion.