Little faced a fitness battle after picking up a knee injury in his side's 2-0 victory over Berwick Rangers in the Ramsden's Cup on Tuesday.
Today is East Fife's first league visit to Ibrox since October 1973 and they will be looking to build on last week's 2-1 win at home to Arbroath – their first of the season.
Former Hearts and Scotland defender Robbie Neilson is included as a trialist for the visitors.
Rangers: Bell; McAusland, Cribari, Faure, Wallace; Crawford, Black, Macleod, Templeton; McCulloch, Clark
East Fife: Andrews; Dutot, Thom, Neilson, Mbu, Johnstone; Brown, Willis, J. Stewart, Tuta; Buchanan