The Reds incredibly missed out on a playoff spot on the final day of the 2019-20 campaign, eventually finishing in seventh, while QPR ended the season in 13th position in the table.
QPR will have to do without the services of Eberechi Eze in the coming season as the 22-year-old, who scored 14 times in the Championship last season, has left to join Premier League side Crystal Palace.
Mark Warburton's side finished 13th in the Championship last season, 12 points outside of the playoffs, and it is going to be difficult for the team to push for the top six positions in 2020-21.
The home side will also enter this game off the back of a disappointing result, having suffered a 3-2 defeat away to Plymouth Argyle in the first round of the EFL Cup last weekend.
Forest, meanwhile, also exited the EFL Cup in the first round last Saturday, suffering a 1-0 defeat to Barnsley, but there is no question that their main focus will again be on the Championship this season.
The Reds needed a draw on the final weekend of the 2019-20 campaign against Stoke City to make sure of a spot in the playoffs, but a 4-1 loss saw Swansea City move into sixth position on goal difference.
Forest actually failed to win any of their final six league matches of the season as they incredibly missed out on the opportunity to play for a spot in the Premier League.
Sabri Lamouchi's side cannot afford to dwell on the disappointment, though, and they will be determined to start their campaign with a positive result on Saturday afternoon.
There are likely to be some new faces on display for the visitors, but a key player has been lost this summer, with right-back Matty Cash joining Premier League side Aston Villa.
Queens Park Rangers pre-season form: WL
Queens Park Rangers form (all competitions 2020-21): L
Nottingham Forest form (all competitions 2020-21): L
Bright Osayi-Samuel's future remains the subject of much speculation, and there is a chance that the 22-year-old will be left out of the squad as he is yet to commit his future to the club.
Dykes should make his Championship debut for the club, though, with the forward expected to shake off the knock that he suffered while representing Scotland in the UEFA Nations League.
Queens Park Rangers possible starting lineup:
Lumley; Kakay, Dickie, Barbet, Manning; Ball, Carroll; Thomas, Amos, Chair; Dykes
Nottingham Forest possible starting lineup:
Smith; Gabriel, Figueiredo, Worrall, Ribeiro; Ameobi, Carvalho, Bachriou, Colback, Da Costa; Grabban
We say: Queens Park Rangers 0-2 Nottingham Forest
Forest will be determined to put three points on the board as they bid to move on from last season, and we fancy the visitors to have too much for QPR on Saturday, backing a 2-0 success for the Reds.