However, QPR were unable to respond to their defeat against Wigan, and as a result will be unable to move back to the top of the table even if they win at Loftus Road on Saturday, but they could leapfrog Leicester City into second place.
For Derby, they sit nine points adrift of their opponents this weekend, but the arrival of new boss McClaren has boosted the Rams, resulting in two victories and one draw since the ex-England boss took over.
Despite a positive run, Derby have only kept one clean sheet this season, which QPR could capitalise on as they have netted 14 goals in 13 fixtures so far in the campaign.
The last time these two clubs met was back in 2011 at QPR's home turf, but neither side could find the breakthrough, resulting in a goalless affair and one point apiece.
Queens Park Rangers: WWWDLD
Derby County: LLDWWD
Possible starting lineups
Queens Park Rangers: Green; Simpson, Dunne, Hill, Assou-Ekotto; Jenas, Barton, O'Neil, Hoilett; Kranjcar, Austin
Derby County: Grant; Wisdom, Keogh, Buxton, Forsyth; Bryson, Eustace, Hughes, Ward; Dawkins, Martin
Sports Mole says: 2-1