PSV vs. FC Twente (Saturday, 3.30pm)
This is the second meeting between the sides this season, following a 1-1 draw in November at the Grolsch Veste Stadium.
We say: PSV Eindhoven 3-1 FC Twente
PSV will be looking to bounce back from their disappointing defeat last time out and given the form of the side they will be going up against, they should be able to manage that in a relatively comfortable manner.
PEC Zwolle vs. RKC Waalwijk (Saturday, 5.45pm)
Zwolle were denied all three points very late in the reverse meeting, where Finn Stokkers levelled the game at 1-1 within three minutes of coming off the bench.
We say: PEC Zwolle 2-0 RKC Waalwijk
Zwolle have struggled at home this season but so have Waalwijk away from it. Clearly, something has to give in this one, and a home victory just about looks like the more probable outcome.
Emmen vs. AZ (Saturday, 7.00pm)
On the other hand, Emmen are still without a league victory 20 games into the season, and it would take a massive turnaround from hereon in to see them avoid relegation.
We say: Emmen 0-2 AZ Alkmaar
It is almost impossible to envisage where Emmen's first league win of the season is going to come from, and the visit of AZ is expected to spell another defeat for the home side, who simply look too vulnerable at the moment.
Heerenveen vs. Vitesse (Saturday, 8.00pm)
We say: Heerenveen 1-2 Vitesse
Vitesse may not be in a position to win the title, but securing second place is a very realistic target and victories in games of this nature are a necessity if that is to be achieved.