Milan reached the knockout stages last season before being squeezed out by Barcelona, despite earning a famous 2-0 win at the San Siro in the first leg.
Dutch side PSV now stand in the way of a place in the group stages for Massimiliano Allegri's men, who have been relatively quiet in the transfer market this summer.
PSV are sweating on the fitness of key duo Karim Rekik and Stijn Schaars, although the pair overcame knocks to play last weekend, in a match which marked a fifth successive league win for Phillip Cocu's side.
PSV: Zoet, Willems, Bruma, Rekik, Arias, Wijnaldum, Hiljemark, Maher, Depay, Locadia, Jozefzoon
Milan: Abbiati, Constant, Mexes, Zapata, Abate, Poli, De Jong, Montolivo, Shaarawy, Balotelli, Boateng
Sports Mole says: 1-1