Ukraine are currently top of the section with 16 points - five points clear of second-placed Portugal, who have a game in hand as the two teams battle for first spot in the group.
Monday's clash will be a much tougher assignment for the UEFA Nations League winners, though, as they look to halt the progress of Andriy Shevchenko's in-form side.
Here, Sports Mole looks at how Portugal could line up on Monday night.
Portugal were without the services of holding midfielder William Carvalho on Friday night through injury; that will again be the case for this match, meaning that Danilo Pereira should start in the middle of the park.
Ruben Neves for Wolverhampton Wanderers teammate Joao Moutinho is an alteration that could occur in the middle of the park, although there are not expected to be many changes from the clash with Luxembourg.
Bernardo Silva, Joao Felix and Ronaldo are almost certain to continue as the front three in a 4-3-3 formation, with Guedes starting on the bench despite registering a late goal last time out.
Pepe and Ruben Dias are largely expected to continue in central defence, while goalscoring midfielder Bruno Fernandes - strongly linked with Manchester United over the summer - will keep his spot in the middle of the park.