Braga have not appeared in the final of this tournament since 2016 when they beat Porto on penalties to win their second-ever title.
Porto were involved in a share of the spoils for the third league game running as they held Sporting Lisbon to a goalless draw on Saturday.
Sergio Conceicao's men had an opportunity to close the 10-point gap between themselves and the league leaders, but they were unable to do so.
They head into their semi-final second leg off the back of a 1-1 draw in the first leg at the Estadio Municipal de Braga three weeks ago.
The tie remains firmly in the balance, and the home team will look to take an important step towards success in what is perhaps their best shot at silverware this season.
Back home, Os Arcebispos are nine points behind Sporting Lisbon in the race for the title and with 13 games left to play, they have an outside chance of being crowned champions.
In the meantime, securing a place in May's showdown is the target, but they have lost four of their last five games away at Wednesday's hosts.
Porto Taca de Portugal form: WWWW
Porto form (all competitions): DDDWWD
Braga Taca de Portugal form: WWWW
Braga form (all competitions): DWLWLW
After almost a year out with a knee problem, Ivan Marcano returned to action on Saturday albeit with the reserve team as he works his way back to full fitness.
Mouhamed Mbaye has not featured for the home team since last July when he ruptured his anterior cruciate ligament a few minutes after coming on as a substitute.
David Carmo is the away side's only other absentee after he hobbled off with an ankle injury in the most recent meeting between the teams.
Porto possible starting lineup:
Marchesin; Sanusi, Pepe, Mbemba, Manafa; Uribe, Vieira, Otavio; Diaz, Marega, Corona
Braga possible starting lineup:
Magalhaes; Esgaio, Rodrigues, Tormena, Borja; Galeno, Fransergio, Musrati, Horta; Ruiz, Piazon
We say: Porto 2-1 Braga
The two teams are renowned for being deadly in attack which should make for a game full of goals. However, we expect Porto to narrowly edge out their opponents, and secure a place in the final.