Jagoba Arrasate's side will enter the match off the back of a 1-0 defeat at Getafe, while Levante have played just once in the league this season, suffering a 4-2 loss at Valencia on the opening weekend.
After two seasons in the second tier, Osasuna finished 10th in La Liga last season and were ultimately just four points off the Europa League spots during an impressive top-flight campaign.
Osasuna could not build on the victory over the newly-promoted side, though, suffering a 1-0 defeat to Getafe last time out, meaning that they will be determined to bounce back on Sunday.
Los Rojillos, who are currently sixth in La Liga, recorded a 2-0 victory in the corresponding match between the two teams last season, but Levante have been victorious in two of their last four top-flight encounters.
Levante, as mentioned, suffered a 4-2 defeat at Valencia in their season opener on September 13; Paco Lopez's side actually led 2-1 at the Mestalla late in the first period but were on the wrong end of the final scoreline.
The Frogs finished 12th in Spain's top flight last term, which actually represented their highest placing at this level of football since 2013-14.
The need for a positive result against Osasuna on Sunday is perhaps strengthened by the fact that their next two league fixtures after this one are against Sevilla and Real Madrid.
Osasuna La Liga form: WL
Levante La Liga form: L
Dani Gomez and De Frutos, who both arrived from Real Madrid this summer, came off the bench against Valencia and are likely to be among the substitutes once again.
Osasuna possible starting lineup:
Herrera; Roncaglia, Navas, D Garcia, Cruz; Torres, Oier, Moncayola, Perez; Adrian, R Garcia
Levante possible starting lineup:
Fernandez; Miramon, Duarte, Rober, Clerc; Campana, Radoja, Melero, Bardhi; Leon, Morales
We say: Osasuna 2-1 Levante
Both teams will feel that they can cause issues in the final third of the field, and it should be an interesting match in Pamplona. We are not predicting too many goals at Estadio El Sadar but expect Osasuna to shade a tight match, moving onto six points in the table as a result.