The home side started brightly and Valentin Eysseric was particularly confident early on, as he struck a long-range free kick not too far over the crossbar.
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It was still 0-0 at the break, but just five minutes into the second half Nice went ahead. Eysseric was the scorer with a low drive from the edge of the box following a corner routine.
Reims piled forward in search for an equaliser, but De Preville missed their best chance with a 75th-minute header, and they were unable to claim the point that they wanted.