Gonzalo Higuain and Lorenzo Insigne, who have scored 15 goals between them in all competitions this season, continue in attack, while Dries Mertens is fit enough only for a place as a substitute after missing the last two matches with a thigh injury.
Napoli: Reina; Albiol, Ghoulam, Hysaj, Chiriches; Jorginho, Hamsik, Lopez, Callejon; Higuain, Insigne
Subs: Rafael, Gabriel, Strinic, Henrique, Maggio, Chalobah, Allan, Valdifiori, Koulibaly, El Kaddouri, Mertens, Gabbiadini
Palermo: Sorrentino; Lazaar, Gonzalez, Andjelkovic, Rispoli; Struna, Hiljemark, Rigoni, Maresca; Gilardino, Vazquez
Subs: Colombi, Vitiello, Goldaniga, Daprela, El Kaoutari, Pezzella, Brugman, Chochev, Quaison, Jajalo, Trajkovski, La Gumina