Bologna vs. Roma (Wednesday, 5.30pm)
Meanwhile, Bologna have recorded three victories in four outings, a run of form which has resulted in Sinisa Mihajlovic's side emerging as contenders for the European places.
We say: Bologna 1-1 Roma
While Roma have consistently performed well at Stadio Olimpico this season, that has not always been the case away from home. With that in mind, we are going to predict a low-scoring draw, a result which may be regarded as satisfactory by both clubs.
Inter Milan vs. Spezia (Wednesday, 5.30pm)
Returning to San Siro just a point behind city rivals Milan and four adrift of leaders Napoli, the Nerazzurri will be seeking an eighth win from 10, while their visitors are languishing just a point above the drop zone after their latest loss on Sunday.
We say: Inter Milan 3-0 Spezia
There should be no expectations other than a comfortable home win at San Siro, due to the combination of Inter's fine form and Spezia's calamitous approach to defending.
Even if Simone Inzaghi opts to rotate his resources, the quality at his disposal far outweighs his imperiled counterpart, whose reign as boss of the visitors could be coming to an end if their fortunes do not improve soon.
Genoa vs. AC Milan (Wednesday, 7.45pm)
Seeking to halt their losing run, the Rossoneri start the final month of a rollercoaster year against Andriy Shevchenko's new side, who sit 18th in the table.
We say: Genoa 1-2 AC Milan
Although Milan have been far from their best in recent days, the opportunity to take on Genoa should present them with a straightforward three points to steady the ship a little, before greater tests to come.
A distinct lack of goal threat from the hosts should embolden their more illustrious visitors, who have scored goals from numerous sources this term and will find a way through at least once over the course of 90 minutes.
Sassuolo vs. Napoli (Wednesday, 7.45pm)
Napoli make the trip to Sassuolo on Wednesday evening looking to retain their three-point advantage at the top of the Serie A standings.
While Sassuolo have endured a disappointing campaign thus far, collecting four points from two games has moved Alessio Dionisi's team into 12th position.
We say: Sassuolo 1-3 Napoli
On the back of their terrific victory at Milan, Sassuolo head into this fixture full of confidence. Nevertheless, we cannot back against Napoli right now, the visitors having the firepower to make relatively light work of their mid-table hosts.