Higuain came close early on for the visitors, but he could only place his effort from the edge of the box wide of the post.
David Lopez was the next to threaten for Napoli with a powerful strike from range that went just over the bar.
Napoli looked the team more likely to open the scoring and Dries Mertens fired a powerful drive from the edge of the box just wide.
Jose Callejon should have brought Napoli level just minutes later, but somehow he fired the ball over the bar from just a yard out.
With seven minutes left to play the hosts were reduced to 10 men after Luca Cigarini picked up his second booking of the match.
Napoli made their numerical advantage count almost immediately as three minutes later Higuain equalised when he collected Lorenzo Insigne's cross before turning and firing a low effort into the corner.
Higuain stepped up to take the spot kick, but he saw his effort saved by Sportiello as the game finished in a draw.