© Getty Images
With four minutes of the first half remaining Napoli equalised. Dries Mertens drove through the midfield and lashed a strike into the top corner and out of the reach of Berisha.
Three minutes into the second half Lazio were reduced to 10 men, when Lorik Cana brought down Mertens inside the box and picked up his second yellow card of the afternoon.
From the resulting penalty, Higuain stepped up and made no mistake to calmly score past Berisha.
In the 67th minute Higuain scored his side's third of the afternoon, when he latched onto Insigne's through-ball and fired a strike into the net.
Insigne came close to a fourth goal soon after, but saw his powerful long-range attempt beaten away by the keeper.
With eight minutes of the game left to play, Lazio boosted their hopes of earning a point as Ogenyi Onazi ran through before slotting home from close range.
In the final minute of stoppage time Higuain sealed the win for the hosts, as he found space in the box before lifting the ball over the keeper to complete his hat-trick.