Record-breaking Atalanta BC tackle the first of seven games in 23 days, which could underscore their challenge for honours this season, as they visit Gennaro Gattuso's Napoli at Stadio San Paolo on Saturday afternoon.
Looking for a fourth Serie A win on the spin, the buoyant Bergamo side will encounter a Partenopei who themselves had scored an impressive eight goals in their opening two matches - before controversy struck.
Two of the most entertaining teams on the peninsula last met at the beginning of July, with Atalanta claiming the three points after a 2-0 win. Napoli have, in fact, failed to win any of their last three head-to-head clashes, managing only one draw in the process.
There is no doubt that both sides will see the other as a significant threat in the long race for a top four place and are committed to taking all three points from this edition.
Atalanta dismantled Cagliari 5-2 last time out to surge alongside leaders AC Milan on maximum points from their first trio of games, while their Neapolitan hosts' hotly-anticipated fixture with Juventus was called off amid bizarre circumstances.
Napoli failed to make the journey to Turin - due to two positive COVID-19 tests at the club - leaving Juve jilted and waiting pitchside for an opposition that never arrived.
Though Serie A administrators have since harshly punished them with a 0-3 'defeat' and a one point deduction as a result, Napoli's on-field start to the campaign will still have offered renewed hope to a passionate fanbase of their first scudetto since 1990.
That non-game aside, a run of four straight victories - scoring 16 goals in the process and keeping a clean sheet in all four - supports such ambitions for the success-hungry southern side.
Post-international break, all squad members came through a rigorous local testing regime in Naples to be ready for this early-season crunch clash. It remains to be seen how time inside their secure 'bubble' at Castel Volturno, where they remain until Saturday, will affect Gattuso's preparations.
Atalanta, meanwhile, are on a four-game winning streak, scoring 17 goals, though have not yet kept a clean sheet. La Dea have lost just two of their last 20 games in all competitions and recorded 15 victories during a golden period for the club.
In fact, Gian Piero Gasperini's charges are the first team in Serie A history to score at least four goals in each of their opening three games of the season.
The latest on a long list of relatively obscure signings, Dutch forward Sam Lammers, impressed from the bench last time out - scoring his first Serie A goal against Cagliari after a flurry of stepovers.
With such firepower at the disposal of two wildly contrasting managers, there will surely by a glut of goals to enjoy. With Napoli's home power negated by the continued absence of fans in Italian stadia, the points are very much up for grabs.
Napoli Serie A form: WW
Atalanta Serie A form: WWW
Napoli possible starting lineup:
Ospina; Di Lorenzo, Manolas, Koulibaly, Hysaj; Fabian Ruiz, Lobotka; Politano, Lozano, Mertens; Osimhen
Atalanta possible starting lineup:
Sportiello; Romero, Palomino, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Gomez; Muriel, Zapata
We say: Napoli 2-2 Atalanta
Gasperini's commitment to attack knows no bounds, so it should be expected that La Dea will bring their sparkling brand of football to one of the grandest stages in Italian football.
Napoli boast a rich abundance of attacking talent themselves and this could be the time for expensive new recruit Victor Osimhen to really establish his credentials as their number one no. 9 by bagging at least one goal in an end-to-end encounter.