The Italian top flight has undergone numerous changes to the number of sides competing in any one season, last having 16 teams in the 1987-88 campaign.
In 1988, the number of teams in Serie A was increased to 18, before being changed again in 2004 to the current 20.
"Football in Italy is led by people who have the mentality of 20-30 years ago," De Laurentiis told Radio 24.
"In 1986, Serie A had 16 teams, and if that was still the case, everyone would be happier. I would cut the number of clubs participating with just one relegation spot.
"I spoke to [FIGC president Carlo] Tavecchio about this. There are teams that lose 6-0 and it's no good for anyone.
"It won't happen, though. [TV rights company] Infront lie to the small clubs, but it's no good for those who want Italian football to be competitive."