Nantes are second-last on the ladder but just two points adrift of safety, while Reims are out to push away from the chasing pack in 13th spot.
La Maison Jaune have struggled to notch victories this season, with just four from their 27 matches, and have a leaky defence that has already shipped 42 goals.
Finishing off opponents has been a major issue for the West coast outfit as they have registered 12 draws, the most of any side in the competition.
Nantes' past two matches have both ended in stalemates, with consecutive 1-1 results against Nimes and Marseille.
In contrast, their opponents Les Rouges et Blancs have been only marginally sharper in both attack and defence with seven wins, 10 draws and 10 defeats from their league fixtures.
However, Reims head into the contest amid a worrying five-game winless run, compounded by last week's 0-0 draw with Montpellier.
A mere seven points separates these two sides in the table, and Nantes have the opportunity to cut that gap to four on Wednesday.
The pair last met on December 16 when Reims edged a tight contest at the Stade Auguste-Delaune 3-2 thanks to Mathieu Cafaro's winner.
Nantes Ligue 1 form: DDWLDL
Nantes form (all competitions): DLLWDD
Reims Ligue 1 form: DDDLDW
Reims form (all competitions): DLLDDD
Forward Kalifa Coulibaly is also unavailable with a thigh complaint, but is expected to return within the next fortnight.
The key man for Nantes is attacking midfielder Ludovic Blas, with the 23-year-old top-scoring for his club with six goals and three assists this season.
Reims coach Guion has no injury concerns heading into this clash.
Nantes possible starting lineup:
Lafont; Appiah, Girotto, Castelletto, Traore; Blas, Chirivella, Toure, Louza; Simon, Kolo Muani
Reims possible starting lineup:
Rajkovic; Foket, Munetsi, Faes, Konan; Mbuku, Cassama, Berisha; Kutesa, Dia, Zeneli
We say: Nantes 1-1 Reims
Both of these teams are increasingly desperate and have trouble turning leads into victories, with a draw the most likely result.