In all, Boro boss Garry Monk makes four changes from the side that lost 1-0 at Wolverhampton Wanderers last weekend, with Bamford's impressive display after coming on from the bench earning him a starting spot tonight.
Marten de Roon's exit for Atalanta allows Adam Forshaw back into the midfield alongside Adam Clayton and Jonny Howson, while Dael Fry replaces Daniel Ayala as partner for Ben Gibson in the heart of defence.
For Sheffield, Chris Wilder names an unchanged XI from the side that defeated Brentford 1-0 last weekend as he looks to extend the club's record run of eight straight league wins.
Middlesbrough: Randolph; Christie, Fry, Gibson, Friend; Clayton, Howson, Forshaw; Bamford, Assombalonga, Gestede
Subs: Dimi, Fabio, Roberts, Leadbitter, Baker, Traore, Fletcher
Sheffield United: Blackmanl Stevens, O'Connell, Basham, Stearman, Freeman; Carruthers, Coutts, Fleck; Sharp, Clarke
Subs: Eastwood, Lundstram, Wright, Duffy, Lafferty, Evans, Brooks
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