Wigan travel to the Riverside Stadium on the back of a 2-1 success over Crystal Palace in the fourth round of the FA Cup.
Manager Uwe Rosler has lost just twice in 11 matches in charge of the Latics, who need to improve on the road after just four away wins all season.
Wigan Athletic: WDWWLW
Possible starting lineups
Middlesbrough: Given; Varga, Friend, Ayala, Williams; Leadbitter, Adomah, Whitehead, Carayol, Ledesma; Emnes
Wigan Athletic: Al-Habsi; Perch, Beausejour, Boyce, Barnett; McArthur, McManaman, Watson, Espinoza, McClean; Maynard
Sports Mole says: 1-1