The Red Devils are simply aiming to consolidate second spot in the table, while Liverpool remain rank outsiders for a Champions League place, and here Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Henderson; Wan-Bissaka, Lindelof, Bailly, Shaw; Fred, McTominay; Rashford, Fernandes, Pogba; Cavani
Out: Virgil van Dijk (knee), Joe Gomez (knee), Joel Matip (ankle), Jordan Henderson (groin), Divock Origi (muscle), Naby Keita (muscle), Ben Davies (muscle), Caoimhin Kelleher (abdominal), Ozan Kabak (muscle), James Milner (unspecified)
Sports Mole's predicted XI: Alisson; Alexander-Arnold, Phillips, Williams, Robertson; Fabinho, Thiago, Wijnaldum; Salah, Firmino, Mane
Watch the Sports Mole Football Shorts prediction for this game below: