Manchester United and Tottenham Hotspur have made three changes apiece for Saturday lunchtime's Premier League clash at Old Trafford.
The Lilywhites are without top scorer Harry Kane for their trip to the Theatre of Dreams, forcing manager Mauricio Pochettino into a tactical reshuffle.
Serge Aurier, Eric Dier and Moussa Sissoko are the players to come in on the back of the 4-1 win against Liverpool last time out in the top flight, replacing Kieran Trippier, Davinson Sanchez and Kane.
Pochettino has gone with a three-man backline, with Ben Davies and the returning Aurier being utilised at wing-back, while makeshift forward Son Heung-min is likely to lead the line in the absence of Kane.
In terms of the hosts, who sit one place better off than their opponents due to a superior goal difference, boss Jose Mourinho has also seemingly gone with a back three.
Eric Bailly has overcome an injury concern to return to the side following last weekend's 2-1 loss at Huddersfield Town, partnering Phil Jones and Chris Smalling in defence.
Mourinho also recalls Henrikh Mkhitaryan and Marcus Rashford to the starting XI, with Juan Mata, Jesse Lingard and Anthony Martial each dropping down to the bench.
United have won their last three Premier League home games against Tottenham without conceding a goal, while going further back they have only lost four of their last 32 top-flight fixtures with Spurs overall.
Manchester United: De Gea; Bailly, Jones, Smalling; Valencia, Herrera, Matic, Young; Mkhitaryan, Lukaku, Rashford
Subs: Romero, Blind, Darmian, McTominay, Lingard, Mata, Martial
Tottenham Hotspur: Lloris; Alderweireld, Dier, Vertonghen; Davies, Winks, Sissoko, Eriksen, Aurier; Son, Alli
Subs: Vorm, Rose, Sanchez, Trippier, Dembele, Nkoudou, Llorente
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