Red Devils boss Jose Mourinho has kept faith with the bulk of the side which beat Tottenham Hotspur 2-1 in last week's FA Cup semi-finals, with just Phil Jones dropping out of the squad in place of Victor Lindelof.
In contrast, Arsene Wenger has made eight changes to his lineup, with an eye on Thursday's Europa League semi-final second leg at Atletico Madrid.
Calum Chambers and Konstantinos Mavropanos start at centre-back, while Granit Xhaka will captain the side and 19-year-old defender Jordi Osei-Tutu, who is yet to make a first-team appearance, is on the bench.
Manchester United: De Gea; Valencia, Lindelof, Smalling, Young; Herrera, Matic, Pogba; Lingard, Sanchez; Lukaku
Subs: Pereira, Rojo, Mata, Martial, Rashford, Fellaini, McTominay
Arsenal: Ospina; Bellerin, Chambers, Mavropanos, Kolasinac; Xhaka, Maitland-Niles; Iwobi, Nelson, Mkhitaryan; Aubameyang
Subs: Cech, Holding, Monreal, Osei-Tutu, Willock, Welbeck, Nketiah
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