Javier Hernandez comes into the starting lineup for the first time in 2014, while Anders Lindergaard is handed a first start since the 5-5 draw against West Bromwich Albion last season, with David de Gea among the substitutes.
Newcastle have made three changes from the side which lost 4-0 against Southampton last time out, with Dan Gosling, Davide Santon and Luuk de Jong returning in place of Moussa Sissoko, Mapou Yanga-Mbiwa and Hatem Ben Arfa.
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Manchester United: Lindegaard; Valencia, Jones, Smalling, Evra; Young, Mata, Fletcher, Fellaini, Kagawa; Hernandez
Subs: De Gea, Büttner, Vidic, Cleverley, Januzaj, Nani, Wilson
Newcastle United: Elliot; Santon, Williamson, Coloccini, Haidara; Anita, Gosling, Tiote, Gouffran; De Jong, Cisse
Subs: Alnwick, S.Taylor, Yanga-Mbiwa, Dummett, Ben Arfa, Shola Ameobi, Armstrong