The Spaniard had been strongly linked with a switch to Real Madrid all summer, meaning that Sergio Romero was trusted between the sticks.
With the transfer window now over, and De Gea still a United player, Louis van Gaal has opted to throw his trusted stopper back into the mix for this evening's crunch clash.
There is some bad news for home supporters, however, as the recent injury picked up by Wayne Rooney has kept him out of the matchday squad.
Liverpool have made just the one change from their disappointing 3-0 defeat to West Ham United last time out.
Liverpool head to the home of their rivals on the back of a run that has seen them avoid defeat on just one of their last eight visits.
Manchester United: De Gea; Darmian, Smalling, Blind, Shaw; Carrick, Schweinsteiger; Mata, Herrera, Memphis; Fellaini
Subs: Romero, McNair, Rojo, Schneiderlin, Valencia, Young, Martial
Liverpool: Mignolet; Clyne, Skrtel, Lovren, Gomez; Lucas, Can, Milner, Firmino; Ings, Benteke
Subs: Bogdan, Toure, Sakho, Moreno, Origi, Rossiter, Ibe
Hit 'play' below to see what the Sports Mole Sofa had to say about the match:
Follow all of the action from this afternoon's game with Sports Mole's live text commentary.