United have endured a difficult season under new manager David Moyes, but three wins from their last four games suggests that they have turned a corner.
United will be keen to avenge their 4-1 defeat away to the Blues back in September when goals from Yaya Toure and Samir Nasri, combined with a Sergio Aguero brace, saw the former champions thrash their neighbours.
Robin van Persie is missing for the hosts with an ankle injury while Nemanja Vidic misses out through suspension. Antonio Valencia is likely to face a late fitness test after suffering an eye problem against Olympiacos last week.
Man Utd: WLWLWW
Man City: WWLLWW
Possible starting lineups
Man Utd: De Gea; Evra, Ferdinand, Jones, Rafael; Carrick, Fletcher; Mata, Rooney, Kagawa; Welbeck
Man City: Hart; Zabaleta, Lescott, Kompany, Kolarov; Fernandinho, Toure, Milner; Nasri, Silva, Negredo
Sports Mole says: 2-2