The Whites have won just one of three home league games so far this season and have lost two in a row in all competitions.
United have come in for criticism early in the season but their two most recent games have shown signs of improvement; they came from behind twice to beat Stoke City in the league before thrashing Norwich City 4-0 in the League Cup.
United have Danny Welbeck pushing for a return, and there are likely to be a host of changes from both managers after resting names for their respective League Cup clashes.
Possible starting lineups
Fulham: Stekelenburg; Riether, Senderos, Amorebieta, Richardson; Sidwell, Parker; Ruiz, Berbatov, Kasami; Bent
United: De Gea; Smalling, Jones, Vidic, Evra; Januzaj, Carrick, Cleverley, Kagawa; Rooney, van Persie
Sports Mole says: 0-3