Fulham play host to Ole Gunnar Solskjaer's in-form side sitting in the relegation zone and seven points adrift of safety.
Many perceived Fulham's comeback victory over Brighton & Hove Albion at the end of January to potentially be the turning point in the club's season, but last weekend's defeat to Crystal Palace has halted their momentum.
Claudio Ranieri would have regarded the short trip to Selhurst Park as an opportunity to move back within touching distance of their rivals above them, but the 2-0 setback has left Fulham well adrift of safety.
There are still 13 games to be played but with United, Chelsea, Liverpool and Manchester City all to come before the end of March, Ranieri will know that survival is becoming an increasingly difficult task.
Fulham have a favourable run of fixtures from the start of April, but Ranieri is aware that he needs to put the club in a position where three or four wins from their last half-a-dozen outings can make a difference.
Ranieri has witnessed his team register eight points from their last eight games in the top flight - a respectable effort given that there are a number of teams in the Premier League who are averaging below a point per match - but four setbacks in five have put the team on the back foot.
Clean sheets have proven to be a problem all season, but Fulham have also struggled for goals, with the four strikes against Brighton representing the only time that more than one goal has been netted in a top-flight game since the start of December.
Aleksandar Mitrovic and Andre Schurrle have 16 goals between them, but they will require help from their teammates if Fulham are to have any chance of avoiding an immediate return to the Championship.
However, Ryan Babel and Lazar Markovic were both added to the squad in January, and Ranieri will hope that the duo can produce the kind of form which once tempted Liverpool into paying big money for each of their signatures.
Recent form: WLLLWL
Recent form (all competitions): LLLLWL
United have not always shown their clinical side in recent weeks, and that was the case as the North-West giants registered a 1-0 victory away at Leicester City last weekend.
However, Solskjaer will be delighted that his squad of players are showing the character to come through tight games after a number of free-flowing performances shortly after his appointment.
The win over Leicester on Sunday was all the more impressive given that United held onto a one-goal lead for 81 minutes plus added-on time, and the Foxes were not short of opportunities at the King Power Stadium.
Solskjaer will want to see the defence and midfield work harder in order to reduce the number of chances which are being created, but keeping a shutout in such circumstances was ideal preparation ahead of the games which are to come during February.
A triple-header of Paris Saint-Germain, Chelsea and Liverpool follows Saturday's match against Fulham, although the focus will remain on trying to add another three points to their Premier League tally with Chelsea and Arsenal faltering around them.
Chelsea's trip to Manchester City this weekend leaves the door open for United to leapfrog the Blues into fourth position and land a psychological blow ahead of their cup showdown at Stamford Bridge on February 18.
United have managed to score in their last 16 outings in all competitions, and given Fulham's concerns at both ends of the pitch, it would come as a surprise if the Solskjaer bandwagon has not generated more speed come 2.30pm on Saturday.
Recent form: WWWWDW
Recent form (all competitions): WWWWDW
Schurrle may be available after missing the trip to Palace with a knock, while Andre-Frank Zambo Anguissa could be back in contention after an ankle problem.
Timothy Fosu-Mensah is unable to play against his parent club, but Markovic may be on the bench after a week training with his new club.
Fulham possible starting lineup:
Rico; Odoi, Le Marchand, Ream, Bryan; Chambers, Seri, Cairney; Babel, Mitrovic, Sessegnon
Manchester United possible starting lineup:
De Gea; Dalot, Lindelof, Jones, Shaw; Fred, Herrera; Sanchez, Pogba, Martial; Lukaku
Head To Head
Saturday's encounter will represent the 84th competitive meeting between the two clubs, with United recording 50 wins in comparison to just 14 victories for Fulham.
The Cottagers have a desperately poor record against United since 2004, with just two successes and three draws being registered during that period.
United have prevailed in eight of the last nine contests in all competitions.
We say: Fulham 1-4 Manchester United
We feel that Fulham will give a good account of themselves this weekend, but United's style of play is perfect for away fixtures and we expect Solskjaer's side to register a convincing victory at Craven Cottage.