Burnley vs. Leicester (Wednesday, 6.00pm)
The Clarets went down 4-0 to Tottenham Hotspur at the weekend and are now winless in three, while Leicester have lost back-to-back games in all competitions.
We say: Burnley 0-1 Leicester City
Injury-hit Leicester cannot afford for their losing run to stretch into a third game, particularly with the chasing pack - Chelsea, Everton, Liverpool and Tottenham - closing in.
No team has won more away Premier League games this season than City's nine and, against a struggling Burnley side, we can see them getting back to winning ways at Turf Moor.
Sheff Utd vs. Aston Villa (Wednesday, 6.00pm)
The Villans returned to winning ways at Leeds United last time out and are six points off the Champions League spots with two games in hand.
Sheff United were beaten 2-0 by Liverpool, meanwhile, and are now 15 points adrift of safety with just 12 more games left to play.
We say: Sheffield United 0-2 Aston Villa
Villa have enjoyed an impressive campaign and still have plenty to play for, whereas Sheffield United now seem to have accepted the inevitable.
The Blades have won just three times all season and we cannot see that figure improving on Wednesday against a Villa side back to winning ways.
Crystal Palace vs. Man Utd (Wednesday, 8.15pm)
The Eagles memorably won 3-1 at Old Trafford earlier this season, but 17 points now separate the two sides in the table with Man United looking to further strengthen their Champions League hopes in midweek.
We say: Crystal Palace 0-1 Manchester United
Manchester United's unbeaten record on the road is hugely impressive and we can see it extending here, although four of their last five away games have ended all square, while they have only scored three goals in that time.
We therefore do not expect to see a high-scoring Manchester United performance, but equally it is difficult to back a Palace side who have struggled to even get shots off lately, yet alone put the ball in the back of the net.