The Gunners head into the Premier League encounter at the top of the table, eight points above United, who are now under the guidance of manager David Moyes.
"It will be a bit strange without Sir Alex Ferguson there on Sunday," Wenger said in a press conference. "It is one of the games where you can build confidence and gain credit. Recently we have not done so well there. What is important is that we trust our quality and show our resilience."
United secured a 2-1 victory over Arsenal the last time the two sides met at Old Trafford.