Toe and groin injuries sustained by the Dutchman, as well as a one-match suspension that Rooney recently received, meant that the duo have not featured in the same United side since the 1-0 victory over Arsenal in early November.
However, Van Persie is now fit and the pair have been tipped to resume their understanding in the Champions League against Shakhtar Donetsk tomorrow evening.
"What I enjoy most is the interaction together, that we both want to play together," the 30-year-old told UEFA's official website. "We both realise that we are better off playing together, because we are stronger when we are playing together, as a partnership. That's the main thing in any partnership.
"So you all have small partnerships in a big partnership, and I think it's very important that you want to work together and you try to feed the ball in to each other, and make each other stronger. You are always stronger, in any sport, in life, when you are doing stuff together. So that makes me really happy.
"With a player of Wayne's calibre, we can go from strength to strength and we can become better - even better than we do it now. I think we've been playing really well together, we've been setting up goals for each other and scoring, which is what I want. One game he will score a couple, the next game I will score a couple."
Rooney and Van Persie have scored 10 goals apiece for the Red Devils this season.