The Chilean forward swapped clubs in a high-profile January move and has slowly started to find his feet in his new Old Trafford surroundings.
Sanchez spent three-and-a-half seasons with Arsenal, scoring 80 times in 165 matches during that spell, but Jones believes that the 29-year-old will now be keen to inflict misery on his ex-employers.
Asked if it will be a strange afternoon for Sanchez, Jones is quoted by the Daily Mail as saying: "Not so much at home. If it was away at the Emirates, it might be a bit different.
"Going back to a place where he's very fond of, knows the pitch and the fans well. So, at home, it's a little bit different, but he'll still get that added incentive to try and put one over on them."
Sanchez has two goals and three assists in his last four outings for United, compared to a combined three in his first 10 matches.