The Red Devils failed to qualify for both the Champions League and the Europa League last term due to their seventh-place finish in the Premier League table.
Despite the initial disappointment of not reaching either competition, Charlton believes that fewer games will help United to turn their recent fortunes around.
"It seems strange that Manchester United aren't involved in European football for a season," he told the Daily Mail. "It's crazy but maybe it can make things easier for us.
"We've started with some new players, we've not been playing well but we will play well. I think that it's going to be a great adventure of how we pull ourselves back round and get back to the way it used to be."
United return to Premier League action on Sunday when they welcome Queens Park Rangers to Old Trafford.