Jose Mourinho's side ended August having suffered back-to-back defeats to Brighton & Hove Albion and Tottenham Hotspur respectively, but three successive wins on the road have provided the Portuguese with a break from negative headlines.
United had made their worst-ever start to a Premier League campaign after three outings this season, but victory this weekend would keep the North-West giants in contention with neighbours Manchester City.
Mourinho has a number of selection issues ahead of welcoming the newly-promoted side, and here Sports Mole looks at how his side could line up at the Theatre of Dreams.
Out: Nemanja Matic (suspended), Marcus Rashford (suspended), Marcos Rojo (knock)
Doubtful: Ander Herrera (ankle), Phil Jones (thigh)
Mourinho will be forced to make a change in midfield with Nemanja Matic having been dismissed for two yellow cards in last week's 2-1 victory over Watford at Vicarage Road.
Rashford will continue to serve his domestic suspension, while Anthony Martial may start on the bench having completed his first 90 minutes in a United shirt this season.
Antonio Valencia appears to be a certain starter with Mourinho only resting the club captain for the Champions League trip to Switzerland due to Young Boys' artificial pitch.