While the hosts have several selection concerns, United come into the game following a rare week's rest - as Sunday's hotly-anticipated Premier League encounter with Liverpool was postponed after supporters protested on the Old Trafford pitch.
Sports Mole now rounds up the latest team news for the two clubs.
Out: Pau Lopez (shoulder), Nicolo Zaniolo (ACL)
Doubtful: Jordan Veretout (muscular), Leonardo Spinazzola (muscular), Amadou Diawara (groin), Pedro (thigh), Stephan El Shaarawy (thigh), Riccardo Calafiori (thigh), Carles Perez (thigh)
Sports Mole's predicted XI: Mirante; Mancini, Smalling, Ibanez; Karsdorp, Cristante, Villar, Peres; Pellegrini, Mkhitaryan; Dzeko
Sports Mole's predicted XI: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Fred; Rashford, Fernandes, Pogba; Greenwood