The Spaniard has made just two competitive starts for Jose Mourinho's side this season but earns a recall after Marouane Fellaini was ruled out following an ankle injury in the 1-0 victory at Southampton on Saturday.
Mourinho makes five alterations to his starting XI following the slender triumph over the Saints, with Anthony Martial replacing Marcus Rashford up front alongside Romelu Lukaku and Henrikh Mkhitaryan.
Chris Smalling and Victor Lindelof are back in alongside Eric Bailly in a three-man defence ahead of David de Gea between the posts, with Antonio Valencia and Phil Jones being rested for the lengthy trip to the Russian capital.
For the hosts, Mario Fernandes is passed fit to start despite suffering a concussion in the goalless derby encounter with Dynamo Moscow at the weekend, while Fyodor Chalov earns a recall up front alongside Brazilian striker Vitinho.
CSKA Moscow: Akinfeev; Vasin, V.Berezutski, Ignashevich; Fernandes, Wernbloom, Golovin, Schennikov; Dzagoev; Chalov, Vitinho
Subs: Pomazun, Berezutski, Kuchaev, Milanov, Nababkin, Natcho, Zhamaletdinov
Manchester United: De Gea; Lindelof, Bailly, Smalling; Young, Matic, Herrera, Blind; Mkhitaryan, Martial; Lukaku
Subs: Romero, Darmian, Tuanzebe, Mata, McTominay, Lingard, Rashford
Keep up with all of the action from Russia this evening with Sports Mole's live text commentary here.