Javier Hernandez comes in to replace Danny Welbeck at the head of Manchester United's attack.
Wayne Rooney, Javier Hernandez and Robin van Persie form a three-man attack for Manchester United's Champions League encounter with Braga.
Darren Fletcher will be the midfield anchor, giving Shinji Kagawa and Tom Cleverley licence to go forward.
Michael Carrick starts in central defence partnered by Jonny Evans, while Alexander Buttner begins at left-back.
Former Newcastle United midfielder Hugo Viana starts in midfield for the Portuguese team, who line up in a 4-4-2 formation.
Man Utd: De Gea; Rafael, Evans, Carrick, Buttner; Fletcher, Cleverley, Kagawa; Rooney, Hernandez, Van Persie
Braga: Beto; Leandro Salino, Nuno Andre, Paulo Vinicius, Elderson; Custodio, Hugo Viana, Ruben Amorim, Alan; Ruben Micael, Eder
Live Commentary: Manchester United 3-2 Braga - as it happened >