United host Chelsea in the Premier League at the weekend, with victory at Old Trafford giving the North-West outfit a clear advantage in their bid to guarantee a top-three place in the top-flight standings.
However, Mourinho has insisted that his attention is solely on the game in Spain against Sevilla, with the Portuguese suggesting that he will not rest any players for the first leg of the last-16 tie.
At a press conference, the 55-year-old told reporters: "I have two important matches but they are so important that the way to do it is to think about just one. It happened the same against Huddersfield, we played them and we didn't save any players for this game.
"We played the game with the players we had available, the only player that didn't played was David de Gea because we have lots of respect for Sergio Romero and we like him to have some matches before the World Cup but every match we give everything.
"Tomorrow we go with everything and at 10.30pm we start thinking about the next one."
United head into the match having lost two of their last three fixtures in the Premier League.